Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

TargetMol Chemicals

Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

16

Research Use Only

114.3 kDa (predicted)

Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3 and 5 ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of interfering with helper virus propagation and promoting its own replication. Inhibits the host cell cycle G1/S, S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication.

-20°C

12352200