ADENOVIRUS-IKKA

Vector Biolabs

ADENOVIRUS-IKKA

5

Other Application

Research Use Only

1E10 PFU/ml

IKKa The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serines residues, which results in targeted degradation of IkB. IkB kinase a (IKKa), previously designated CHUK, interacts with IkB-a and specifically phosphorylates IkB-a on the sites that trigger its degradation, serines 32 and 36. IKKa appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKa is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKa, IKKB and IKKy (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

-80°C

41106621