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Adiponectin (human) ELISA Kit

Research Use Only
AG-45A-0001YEK
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Adiponectin (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.5 to 32ng/ml
  • Assay Sensitivity
    100pg/ml
  • Assay Specificity
    Detects human adiponectin. Does not cross-react with mouse adiponectin, rat adiponectin, human resistin, human RELM-beta or human leptin.
  • Certification
    Research Use Only
  • Scientific Description
    Adiponectin [ACRP30; AdipoQ] is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium). - ELISA Assay. Detects human adiponectin. Does not cross-react with mouse adiponectin, rat adiponectin, human resistin, human RELM-beta or human leptin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum, Urine. Range: 0.5 to 32ng/ml. Sensitivity: 100pg/ml. Adiponectin is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Plasma adiponectin levels in postmenopausal women with or without long-term hormone therapy: J. Ima; Maturitas 54, 65 (2006)
  • Association between hypoadiponectinemia and cardiovascular risk factors in nonobese healthy adults. J.A. Im, et al.; Metabolism 55, 1546 (2006)
  • Relationship of serum adiponectin and resistin levels with breast cancer risk: J.H. Kang, et al.; J. Korean Med. Sci. 22, 117 (2007)
  • Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth: E.S. Kim, et al.; Obesity 15, 3023 (2007)
  • Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations: T. Yasui, et al.; Clin. Chim. Acta 386, 69 (2007)
  • Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats: K. Asada, et al.; Intl. J. Mol. Med. 20, 725 (2007)
  • Retinol binding protein 4, low birth weight-related insulin resistance and hormonal contraception: A. Zugaro, et al.; Endocrine 32, 166 (2007)
  • Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women: K. Kwon, et al.; Kor. Circ. J. 37, 251 (2007)
  • Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women: S.C. Hong, et al.; Menopause 14, 835 (2007)
  • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis: H. Nakayama, et al.; Metabolism 56, 470 (2007)