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Adiponectin (mouse) ELISA Kit

Research Use Only
AG-45A-0004YEK
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Adiponectin (mouse) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.125 to 8ng/ml
  • Assay Sensitivity
    50pg/ml
  • Assay Specificity
    Detects mouse adiponectin. Does not cross-react with human adiponectin, rat adiponectin, mouse resistin, mouse RELM-beta or mouse leptin.
  • Certification
    Research Use Only
  • Scientific Description
    Adiponectin [ACRP30; AdipoQ] is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium). - ELISA Assay. Detects mouse adiponectin. Does not cross-react with human adiponectin, rat adiponectin, mouse resistin, mouse RELM-beta or mouse leptin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.125 to 8ng/ml. Sensitivity: 50pg/ml. Adiponectin is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Chop-deficient mice showed increased adiposity but no glucose intolerance: Y. Ariyama, et al.; Obesity 15, 1647 (2007)
  • Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet: S. Otabe, et al.; Am. J. Physiol. Endocrinol. Metab. 293, E210 (2007)
  • Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes: J. Ahn, et al.; BBRC 364, 972 (2007)
  • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis: H. Nakayama, et al.; Metabolism 56, 470 (2007)
  • Anti-diabetic Effects of Compound K versus Metformin versus Compound K-Metformin Combination Therapy in Diabetic db/db Mice: S.H. Yoon, et al.; Biol. Pharm. Bull. 30, 2196 (2007)
  • Compound K Enhances Insulin Secretion with Beneficial Metabolic Effects in db/db Mice: G.C. Han, et al.; J. Agric. Food Chem. 55, 10641 (2007)
  • Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes: M. Kobayashi, et al.; Endocrinology 149, 5662 (2008)
  • A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice: E.J. Han, et al.; Food Sci. Biotechnol. 17, 1228 (2008)
  • Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice: H. Nakayama, et al.; Metabolism 58, 901 (2009)
  • Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus: M.H. Nan, et al.; J. Drug Target. 18, 67 (2010)