AF647 Anti-Human CD49d Antibody

Reddot Biotech

AF647 Anti-Human CD49d Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

9F10

AlexaFluor 647

ITGA4

integrin subunit alpha 4

269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha-4; integrin alpha-IV; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha

Mouse

IgG1

CD49d is a 150 kD Oe+/- integrin chain known as Oe+/-4 integrin or VLA-4 Oe+/- chain. It forms a heterodimer with either integrin beta1 (Oe+/-4beta1, VLA-4) or beta7 (Oe+/-4beta7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. Oe+/-4beta7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

Human

2°C to 8°C

12352203