AF647 Anti-Mouse CD103 Antibody

Reddot Biotech

AF647 Anti-Mouse CD103 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

M290

0.5 mg/ml

AlexaFluor 647

Itgae

integrin alpha E, epithelial-associated

A530055J10; alph; alpha-E1; alpha-M290; aM290; CD103; integrin alpha M290; integrin alpha-E

Rat

IgG2a

CD103 is a type I transmembrane glycoprotein known as Oe+/-E integrin or Integrin Oe+/-IEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-beta stimulation. In association with integrin beta7, CD103 is expressed as Oe+/-E/beta7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Mouse

2°C to 8°C

12352203