AF647 Anti-Mouse CD8a Antibody

Reddot Biotech

AF647 Anti-Mouse CD8a Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

53-6.7

AlexaFluor 647

Cd8a

CD8 antigen, alpha chain

BB154331; Ly-; Ly-2; Ly-3; Ly-35; Ly-B; Lyt-; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2

Rat

IgG2a

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked Oe+/- and beta chains that form the Oe+/-(CD8a)/beta(CD8b) heterodimer and Oe+/-/Oe+/- homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 Oe+/-/beta heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR Oe+/-/beta T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 Oe+/-/Oe+/- homodimer is expressed on a subset of Oe≥/Oe TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Mouse

2°C to 8°C

12352203