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Chemical Structure
Chemical Structure
Chemical Structure

Afatinib

SYN-1100
SYNkinase
CAS Number439081-18-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight486
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Overview

  • Supplier
    SYNkinase
  • Product Name
    Afatinib [439081-18-2]
  • Delivery Days Customer
    10
  • CAS Number
    439081-18-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C24H25ClFN5O3
  • Molecular Weight
    486
  • Scientific Description
    Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM. - Chemical. CAS: 439081-18-2. Formula: C24H25ClFN5O3. MW: 486. Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

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