Chemical Structure
Chemical Structure
Afatinib [439081-18-2]
SYN-1100
CAS Number439081-18-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight486
Overview
- SupplierSYNkinase
- Product NameAfatinib [439081-18-2]
- Delivery Days Customer10
- CAS Number439081-18-2
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC24H25ClFN5O3
- Molecular Weight486
- Scientific DescriptionAfatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM. - Chemical. CAS: 439081-18-2. Formula: C24H25ClFN5O3. MW: 486. Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
- Storage Instruction2°C to 8°C
- UNSPSC51202000