Afatinib-d6 (dimaleate)

MedChem Express

Afatinib-d6 (dimaleate)

10

Research Use Only

C32H27D6ClFN5O11

724.12

Afatinib-d 6 (dimaleate) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1][2].

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H].O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

12352200