Afatinib impurity 11

MedChem Express

Afatinib impurity 11 [1402086-20-7]

10

1402086-20-7

Research Use Only

99.10

C21H18ClFN4O3

428.84

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC 50 s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt , EGFR L858R , EGFR L858R/T790M and HER2, respectively [1] .

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)C=C

2°C to 8°C

12352200