AF/LE Purified Anti-Mouse CD115 Antibody

Reddot Biotech

AF/LE Purified Anti-Mouse CD115 Antibody

5

Flow Cytometry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

AFS98

0.5 mg/ml

Unconjugated

Csf1r

colony stimulating factor 1 receptor

AI323359; CD115; c-fms; Csf; CSF-; CSF-1 receptor; CSF-1R; CSF-1-R; Csfmr; Fim; Fim-; Fim2; Fim-2; Fm; Fms; macrophage colony-stimulating factor 1 receptor; M-CS; M-CSFR; M-CSF-R; proto-oncogene c-Fms; proto-oncogene fms

Rat

IgG2a

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene products natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Mouse

2°C to 8°C

12352203