AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody

Reddot Biotech

AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody

5

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

10F.9G2

0.5 mg/ml

Unconjugated

Cd274

CD274 antigen

A530045L16Rik; B7 homolog 1; B7h1; PD-; PDCD1 ligand 1; Pdcd1l; Pdcd1l1; Pdcd1lg1; Pdl1; programmed cell death 1 ligand 1

Rat

IgG2b

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-Oe≥ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-Oe≥, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Mouse

2°C to 8°C

12352203