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ProductsBack/Aftin-4 [866893-90-5]
Chemical Structure
Chemical Structure
Chemical Structure

Aftin-4 [866893-90-5]

Research Use Only
AG-MR-C0014
AdipoGen Life Sciences
CAS Number866893-90-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight368.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Aftin-4 [866893-90-5]
  • Delivery Days Customer
    10
  • CAS Number
    866893-90-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C20H28N6O
  • Molecular Weight
    368.5
  • Scientific Description
    Chemical. CAS: 866893-90-5. Formula: C20H28N6O. MW: 368.5. Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimers Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. - Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimers Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase.
  • SMILES
    CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(=N1)N(C)CC1=CC=CC=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Roscovitine targets: protein kinases and pyridoxal kinase: S. Bach, et al.; J. Biol. Chem. 280, 31208 (2005)
  • Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives: L. Tang, et al.; J. Biol. Chem. 280, 31220 (2005)
  • Small-molecule inducers of Abeta-42 peptide production share a common mechanism of action: K. Bettayeb, et al.; FASEB J. 26, 5115 (2012)
  • Aftins increase amyloid-beta42, lower amyloid-beta38, and do not alter amyloid-beta40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?: A. Hochard, et al.; J. Alzheimers Dis. 35, 107 (2013)