AG-14361 [328543-09-5]
27602
CAS Number328543-09-5
Product group Chemicals
Estimated Purity≥98%
Molecular Weight320.4 Da
Overview
- SupplierBPS Bioscience
- Product NameAG-14361 [328543-09-5]
- Delivery Days Customer7
- CAS Number328543-09-5
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC19H20N4O
- Molecular Weight320.4 Da
- Scientific DescriptionAG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.
- Storage Instruction-20°C
- UNSPSC12352200