AG2034

MedChem Express

AG2034

9

Research Use Only

C18H21N5O6S2

467.52

AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase ( GARFT ), with a K i of 28 nM against human GARFT , and it binds with high affinity to the folate receptor ( K d of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a K m of 6.4 microM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC 50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED [1] [2] .

O=C1C2=C(NC(N)=N1)NC[C@@H](S2)CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3

12352200