Ageladine A (dihydrochloride)

MedChem Express

Ageladine A (dihydrochloride)

5

Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase ( MMP ) isolated from the marine sponge Agelas nakamurai , possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1 , MMP-8 , MMP-9 , MMP-12 , and MMP-13 , with IC 50 values of 4.65 microM, 2.79 microM, 907.12 nM, 1.83 microM, 767.57 nM, and 1.09 microM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values [1] [2] .

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