AGI-6780 [1432660-47-3]

Biorbyt

AGI-6780 [1432660-47-3]

16

1432660-47-3

Research Use Only

C21H18F3N3O3S2

481.5111

AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM).

S(C1C([H])=C([H])C(C2=C([H])SC([H])=C2[H])=C(C=1[H])N([H])C(N([H])C1=C([H])C([H])=C([H])C(C(F)(F)F)=C1[H])=O)(N([H])C1([H])C([H])([H])C1([H])[H])(=O)=O

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