AGT Polyclonal Antibody
RD266513A
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetAGT
Overview
- SupplierReddot Biotech
- Product NameAGT Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID183
- Target nameAGT
- Target descriptionangiotensinogen
- Target synonymsalpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; angiotensinogen; ANHU; fetal-liver predominant transporter 1; hFLT1; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203