AIFM1 Polyclonal Antibody

Reddot Biotech

AIFM1 Polyclonal Antibody

5

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Aifm1

apoptosis inducing factor, mitochondria associated 1

Aif; apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor 1, mitochondrial-like; apoptosis-inducing factor, mitochondrion-associated 1; Pdcd8; programmed cell death 8 (apoptosis-inducing factor); programmed cell death protein 8

Rabbit

IgG

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Rat

-20°C

12352203