Western blot analysis of extracts from HUVEC cells, using AIM2 antibody.
Western blot analysis of extracts from HUVEC cells, using AIM2 antibody.
AIM2 Antibody
CSB-PA284032
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetAIM2
Overview
- SupplierCusabio
- Product NameAIM2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID9447
- Target nameAIM2
- Target descriptionabsent in melanoma 2
- Target synonymsinterferon-inducible protein AIM2; PYHIN4
- HostRabbit
- IsotypeIgG
- Protein IDO14862
- Protein NameInterferon-inducible protein AIM2
- Scientific DescriptionInvolved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 By similarity. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. DeYoung K.L., Oncogene 15:453-457(1997). Gregory S.G., Nature 441:315-321(2006).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203