(+/-)-Aiphanol

MedChem Express

(+/-)-Aiphanol [578020-29-8]

5

Research Use Only

C25H24O8

452.45

(+/-)-Aiphanol is a newly discovered stilbenolignan analog. (+/-)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 microM) is particularly strong, while the effect on COX-2 (IC50= 9.9 microM) is relatively weak[1].(+/-)-Aiphanol effectively inhibits VEGFR2 (IC50=0.92 microM). (+/-)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (+/-)-Aiphanol is orally active[2].

OC[C@@H]1[C@@H](C2=CC(OC)=C(C(OC)=C2)O)OC3=CC(/C=C/C4=CC(O)=CC(O)=C4)=CC=C3O1

12131703