Bio-Connect

ALDH1A1 antibody

GTX123973
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityFeline, Human, Mouse, Rat, Zebra Fish
TargetALDH1A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    ALDH1A1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID216
  • Target name
    ALDH1A1
  • Target description
    aldehyde dehydrogenase 1 family member A1
  • Target synonyms
    acetaldehyde dehydrogenase 1; ALDC; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; ALDH1; ALDH11; ALDH-E1; ALHDII; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; HEL12; HEL-9; HEL-S-53e; PUMB1; RALDH 1; RALDH1; retinal dehydrogenase 1; retinaldehyde dehydrogenase 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP00352
  • Protein Name
    Retinal dehydrogenase 1
  • Scientific Description
    This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq]
  • Reactivity
    Feline, Human, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression.
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  • TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness.
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  • Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinsons disease.
    Read more
  • DOPAL initiates alphaSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinsons disease. Masato A et al., 2023 Mar 25, NPJ Parkinsons Dis
    Read more
  • The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres. Kim SH et al., 2021, Cancer Drug Resist
    Read more
  • Regulation of gliomagenesis and stemness through acid sensor ASIC1a. King P et al., 2021 Oct, Int J Oncol
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  • Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity. Takahashi H et al., 2021 Aug 23, Stem Cell Res Ther
    Read more
  • T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models. Morello G et al., 2021 Jul, Cancer Immunol Res
    Read more
  • TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma. Wan J et al., 2020, Front Pharmacol
    Read more
  • PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. Lin YY et al., 2020, Int J Med Sci
    Read more