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ALDH1A1 antibody detects Aldh1a2 protein on whole-mount zebrafish embryos by immunohistochemical analysis.? Sample: Paraformaldehyde-fixed zebrafish embryos. ALDH1A1 antibody (GTX123973) dilution: 1:200.
ALDH1A1 antibody detects Aldh1a2 protein on whole-mount zebrafish embryos by immunohistochemical analysis.? Sample: Paraformaldehyde-fixed zebrafish embryos. ALDH1A1 antibody (GTX123973) dilution: 1:200.
ALDH1A1 antibody detects Aldh1a2 protein on whole-mount zebrafish embryos by immunohistochemical analysis.? Sample: Paraformaldehyde-fixed zebrafish embryos. ALDH1A1 antibody (GTX123973) dilution: 1:200.

ALDH1A1 antibody

GTX123973
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityFeline, Human, Mouse, Rat, Zebra Fish
TargetALDH1A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    ALDH1A1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID216
  • Target name
    ALDH1A1
  • Target description
    aldehyde dehydrogenase 1 family member A1
  • Target synonyms
    ALDC, ALDH-E1, ALDH1, ALDH11, HEL-9, HEL-S-53e, HEL12, PUMB1, RALDH1, aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH class 1, ALHDII, RALDH 1, acetaldehyde dehydrogenase 1, aldehyde dehydrogenase 1, soluble, aldehyde dehydrogenase, liver cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e, retinal dehydrogenase 1, retinaldehyde dehydrogenase 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP00352
  • Protein Name
    Aldehyde dehydrogenase 1A1
  • Scientific Description
    This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq]
  • Reactivity
    Feline, Human, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Guo S, Ramar V, Guo AA, et al. TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness. Cell Mol Life Sci. 2023,80(9):270. doi: 10.1007/s00018-023-04921-6
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  • Martinez PA, Martinez VE, Rani S, et al. Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease. Brain Behav. 2023,13(9):e3150. doi: 10.1002/brb3.3150
    Read this paper
  • Masato A, Plotegher N, Terrin F, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023,9(1):42. doi: 10.1038/s41531-023-00485-1
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  • Kim SH, Fan PW, Hsieh CH, et al. The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres. Cancer Drug Resist. 2021,4(4):866-880. doi: 10.20517/cdr.2021.58
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  • King P, Wan J, Guo AA, et al. Regulation of gliomagenesis and stemness through acid sensor ASIC1a. Int J Oncol. 2021,59(4):pii: 82. doi: 10.3892/ijo.2021.5262.
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  • Takahashi H, Nakashima T, Masuda T, et al. Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity. Stem Cell Res Ther. 2021,12(1):471. doi: 10.1186/s13287-021-02549-6
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  • Morello G, Cancila V, La Rosa M, et al. T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models. Cancer Immunol Res. 2021,9(7):825-837. doi: 10.1158/2326-6066.CIR-20-0645
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  • Wan J, Guo AA, King P, et al. TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma. Front Pharmacol. 2020,11:590723. doi: 10.3389/fphar.2020.590723
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  • Lin YY, Wang CY, Phan NN, et al. PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. Int J Med Sci. 2020,17(11):1639-1651. doi: 10.7150/ijms.46125
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