ALIX / PDCD6IP Polyclonal Antibody
RD82606A
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPDCD6IP
Overview
- SupplierReddot Biotech
- Product NameALIX / PDCD6IP Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID10015
- Target namePDCD6IP
- Target descriptionprogrammed cell death 6 interacting protein
- Target synonymsAIP1; ALG-2 interacting protein 1; ALG-2-interacting protein X; ALIX; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; DRIP4; HP95; PDCD6-interacting protein; programmed cell death 6-interacting protein
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203