ALKBH1-IN-3 prodrug

MedChem Express

ALKBH1-IN-3 prodrug

9

Research Use Only

C18H18N4O4

354.36

ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of a DNA N6-methyladenine demethylase ALKBH1 inhibitor that significantly increases the abundance of 6mA in cells and upregulates the AMPK signaling pathway, thereby inhibiting the viability of gastric cancer cells. ALKBH1-IN-4 prodrug exhibits excellent cellular activity and favorable metabolic exposure in vivo, and holds promise for research in gastric cancer[1].

O=C(C1=CN(C2=NC=C(C=N2)OCC3=CC(OC)=CC=C3)N=C1)OCC

12352200