ALKBH2 Polyclonal Antibody
RD77656A
TargetALKBH2
Product group Antibodies
Overview
- SupplierReddot Biotech
- Product NameALKBH2 Polyclonal Antibody
- Delivery Days Customer5
- Concentration0.4 mg/ml
- Gene ID121642
- Target nameALKBH2
- Target descriptionalkB homolog 2, alpha-ketoglutarate dependent dioxygenase
- Target synonyms2OG-Fe(II) oxy DC1; ABH2; alkB, alkylation repair homolog 2; alkylated DNA repair protein alkB homolog 2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; DNA oxidative demethylase ALKBH2; oxy DC1
- Scientific DescriptionThe Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Storage Instruction-20°C
- UNSPSC12352203