More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Aloesin [30861-27-9]
Chemical Structure
Chemical Structure
Chemical Structure

Aloesin [30861-27-9]

Research Use Only
AG-CN2-0437
AdipoGen Life Sciences
CAS Number30861-27-9
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight394.4
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Aloesin [30861-27-9]
  • Delivery Days Customer
    10
  • CAS Number
    30861-27-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C19H22O9
  • Molecular Weight
    394.4
  • Scientific Description
    C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice. - Chemical. CAS: 30861-27-9. Formula: C19H22O9. MW: 394.4. Isolated from Aloe vera. C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.
  • SMILES
    CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2O1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997)
  • Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002)
  • Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002)
  • Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002)
  • Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005)
  • Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction: H.A. El-Shemy, et al.; Curr. Med. Chem. 17, 129 (2010)
  • UP780, a chromone-enriched aloe composition improves insulin sensitivity: M. Yimam, et al.; Metab. Syndr. Relat. Disord. 11, 267 (2013)
  • Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model: M. Yimam, et al.; Diabetol. Metab. Syndr. 6, 61 (2014)
  • Phytochemical constituents and in vitro radical scavenging activity of different Aloe species: L. Pucini, et al.; Food Chem. 170, 501 (2014)