alpha-Conotoxin MII [175735-93-0]

TargetMol Chemicals

alpha-Conotoxin MII [175735-93-0]

9

175735-93-0

Research Use Only

C67H103N23O22S4

1710.94

alpha-Conotoxin MII is a highly potent and selective competitive antagonist for alpha3beta2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at alpha3beta2 expressed in Xenopus oocytes). Also potently blocks beta3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for alpha3beta2 over alpha2beta2, alpha4beta2 and alpha3beta4.

O=C1N2[C@@](CCC2)(C(=O)N[C@@H](C(C)C)C(=O)N[C@@]3(C(=O)N[C@@H](CC4=CN=CN4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(N)=O)CSSC[C@@](C(=O)N[C@@H](CO)C(=O)N[C@H]1CC(N)=O)(NC(=O)[C@@H](NC(CN)=O)CSSC3)[H])[H])[H]

-20°C

12352200