alpha4 integrin receptor antagonist 3 [863226-74-8]

TargetMol Chemicals

alpha4 integrin receptor antagonist 3 [863226-74-8]

9

Research Use Only

C23H21Cl2N3O6

506.34

Compound 11, an alpha4 integrin receptor antagonist, exhibits oral activity and functions as an antagonist of the alpha4 integrin receptor. It efficiently inhibits the adhesion of K562 cells mediated by the interactions of alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. Compound 11 also shows potential for use in studies using the DSS (dextran sulfate sodium) induced colitis mouse model.

O(C)C1=C(C(=O)N(CCO)N=C1)C2=CC=C(C[C@H](NC(=O)C3=C(Cl)C=CC=C3Cl)C(O)=O)C=C2

-20°C

51202000