alpha7 nAchR-JAK2-STAT3 agonist 1 [2108714-20-9]

TargetMol Chemicals

alpha7 nAchR-JAK2-STAT3 agonist 1 [2108714-20-9]

72

Chemical

Research Use Only

alfa7 nAchR-JAK2-STAT3 agonist 1

C25H30O6

426.5

alpha7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the alpha7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 microM). It has demonstrated positive effects on iNOS, IL-1beta, and IL-1beta in murine macrophages RAW264.7, and inhibited the expression of iNOS, IL-1beta, and IL-6 in mouse macrophages. Additionally, alpha7 nAchR-JAK2-STAT3 agonist 1 suppressed LPS-induced NO release, NF-kappaB activation, and cytokine production, making it useful for studying sepsis.

3 years

O(C(C)=O)C1=C(OC(C)=O)C=CC(CC[C@H](CCCCC2=CC=CC=C2)OC(C)=O)=C1

-20°C

12352200