Bio-Connect

ALPL Polyclonal Antibody

RD70571A
Reddot Biotech
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetALPL
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    ALPL Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    200 ug/ml
  • Conjugate
    Unconjugated
  • Gene ID249
  • Target name
    ALPL
  • Target description
    alkaline phosphatase, biomineralization associated
  • Target synonyms
    alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme; APTNAP; AP-TNAP; HOPS; HPPA; HPPC; HPPI; HPPO; liver/bone/kidney-type alkaline phosphatase; tissue non-specific alkaline phosphatase; tissue-nonspecific ALP; TNALP; TNAP; TNSALP
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203