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Alternariol [641-38-3]

Research Use Only
A4675
LKT Laboratories
Product group Chemicals
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Alternariol [641-38-3]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    Mycotoxin produced by Alternaria; topoisomerase I and II inhibitor, potential ER agonist.
  • UNSPSC
    12352200

References

  • Frizzell C, Ndossi D, Kalayou S, et al. An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):64-71. PMID: 23665424. Solhaug A, Holme JA, Haglund K, et al. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicol Lett. 2013 May 10;219(1):8-17. PMID: 23454835. Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721. Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499. Solhaug A, Vines LL, Ivanova L, et al. Mechanisms involved in alternariol-induced cell cycle arrest. Mutat Res. 2012 Oct-Nov;738-739:1-11. PMID: 23031795. Zhao J, Liu K, Lu J, et al. Alternariol induces DNA polymerase bèta expression through the PKA-CREB signaling pathway. Int J Oncol. 2012 Jun;40(6):1923-8. PMID: 22406678. Fehr M, Pahlke G, Fritz J, et al. Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Mol Nutr Food Res. 2009 Apr;53(4):441-51. PMID: 18727009.