AMFR Antibody, HRP conjugated
CSB-PA333164LB01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetAMFR
Overview
- SupplierCusabio
- Product NameAMFR Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- Gene ID267
- Target nameAMFR
- Target descriptionautocrine motility factor receptor
- Target synonymsE3 ubiquitin-protein ligase AMFR; GP78; RING finger protein 45; RING-type E3 ubiquitin transferase AMFR; RNF45
- HostRabbit
- IsotypeIgG
- Protein IDQ9UKV5
- Protein NameE3 ubiquitin-protein ligase AMFR
- Scientific DescriptionE3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203