AMG-1694 [1361217-07-3]

TargetMol Chemicals

AMG-1694 [1361217-07-3]

4

1361217-07-3

Chemical

Research Use Only

AMG-1694

97.97%

C23H30F3N3O4S2

533.63

AMG-1694, a potent disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

3 years

C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4

-20°C

12352200