AMG-193

MedChem Express

AMG-193

5

Research Use Only

99.48

C22H19F3N4O3

444.41

AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 microM), thereby protecting normal cells with wild-type MTAP[1][2].

O=C(N1[C@@H](C2=CC=C(C=C2)C(F)(F)F)COCC1)C3=NC=C4N=C(N)C(COC5)=C5C4=C3

-20°C,2°C to 8°C

12352200