AMG-548 (dihydrochloride)

MedChem Express

AMG-548 (dihydrochloride)

10

Research Use Only

99.86

C29H29Cl2N5O

534.48

AMG-548 dihydrochloride, an orally active and selective p38alpha inhibitor (Ki=0.5 nM), shows slightly selective over p38beta (Ki=36 nM) and >1000 fold selective against p38gamma and p38delta. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFalpha (IC50=3 nM)[1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms delta and epsilon[2].

O=C1N(C)C(NCC(N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4.Cl.Cl

-20°C

12352200