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ProductsBack/AMG-9810

AMG-9810

S6934

Estimated Purity...

Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
AMG-9810
Delivery Days Customer
9
Certification
Research Use Only
Estimated Purity
...
Scientific Description
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
UNSPSC
51202000