AMG517 [659730-32-2]

Biorbyt

AMG517 [659730-32-2]

16

659730-32-2

Research Use Only

C20H13F3N4O2S

430.403

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

S1C(N([H])C(C([H])([H])[H])=O)=NC2=C(C([H])=C([H])C([H])=C12)OC1C([H])=C(C2C([H])=C([H])C(C(F)(F)F)=C([H])C=2[H])N=C([H])N=1

12352200