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(Aminooxy)acetamide-Val-Cit-PAB-MMAE [2446645-88-9]

HY-153263
MedChem Express
Product group Molecular Biology
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (Aminooxy)acetamide-Val-Cit-PAB-MMAE [2446645-88-9]
  • Delivery Days Customer
    10
  • CAS Number
    2446645-88-9
  • Certification
    Research Use Only
  • Estimated Purity
    97.01
  • Molecular Formula
    C60H97N11O14
  • Molecular Weight
    1196.48
  • Scientific Description
    (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1].
  • SMILES
    C[C@@H](C(N[C@H](C)[C@H](C1=CC=CC=C1)O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CON)=O)=O)=O)=O)=O)=O)=O)OC
  • Storage Instruction
    -20°C
  • UNSPSC
    41115800