Amonafide (dihydrochloride)

MedChem Express

Amonafide (dihydrochloride)

9

Research Use Only

C16H19Cl2N3O2

356.25

Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR) [1] .

O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C.Cl.Cl

12352200