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ProductsBack/Amorfrutin A [80489-90-3]
Chemical Structure
Chemical Structure
Chemical Structure

Amorfrutin A [80489-90-3]

Research Use Only
AG-CN2-0462
AdipoGen Life Sciences
CAS Number80489-90-3
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight340.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Amorfrutin A [80489-90-3]
  • Delivery Days Customer
    10
  • CAS Number
    80489-90-3
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C21H24O4
  • Molecular Weight
    340.4
  • Scientific Description
    Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent. - Chemical. CAS: 80489-90-3. Formula: C21H24O4. MW: 340.4. Isolated from Amorpha fruticosa. Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent.
  • SMILES
    COC1=C(CC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa: L.A. Mitscher, et al.; Phytochemistry 20, 781 (1981)
  • Amorfrutins are potent antidiabetic dietary natural products: C. Weidner, et al.; PNAS 109, 7257 (2012)
  • Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor gamma: J.C. De Groot, et al.; J. Med. Chem. 56, 1535 (2013)
  • Amorfrutin A inhibits TNF-alpha-induced NF-kappaB activation and NF-kappaB-regulated target gene products: H. Shi, et al.; Int. Immunopharmacol. 21, 56 (2014)
  • Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARgamma): a review: L. Wang, et al.; Biochem. Pharmacol. 92, 73 (2014)
  • Amorfrutins Are Natural PPARgamma Agonists with Potent Anti-inflammatory Properties: L. Fuhr, et al.; J. Nat. Prod. 78, 1160 (2015)