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ProductsBack/Amorfrutin B [1174387-94-0]
Chemical Structure
Chemical Structure
Chemical Structure

Amorfrutin B [1174387-94-0]

Research Use Only
AG-CN2-0464
AdipoGen Life Sciences
CAS Number1174387-94-0
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight408.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Amorfrutin B [1174387-94-0, 78916-42-4]
  • Delivery Days Customer
    10
  • CAS Number
    1174387-94-0
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C26H32O4
  • Molecular Weight
    408.5
  • Scientific Description
    Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has low nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. The binding affinity constant to PPARgamma is 12 times lower than Amorfrutin A (Prod. No. AG-CN2-0462). Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Antimicrobial agent. - Chemical. CAS: 78916-42-4 and 1174387-94-0. Formula: C26H32O4. MW: 408.5. Isolated from Amorpha fruticosa. Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has low nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. The binding affinity constant to PPARgamma is 12 times lower than Amorfrutin A (Prod. No. AG-CN2-0462). Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Antimicrobial agent.
  • SMILES
    COC1=C(C\C=C(/C)CCC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa: L.A. Mitscher, et al.; Phytochemistry 20, 781 (1981)
  • Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor gamma: J.C. De Groot, et al.; J. Med. Chem. 56, 1535 (2013)
  • Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARgamma) agonist with potent glucose-lowering properties: C. Weidner, et al.; Diabetol. 56, 1802 (2013)
  • Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARgamma): a review: L. Wang, et al.; Biochem. Pharmacol. 92, 73 (2014)
  • Amorfrutins Are Natural PPARgamma Agonists with Potent Anti-inflammatory Properties: L. Fuhr, et al.; J. Nat. Prod. 78, 1160 (2015)