Amustaline (dihydrochloride)

MedChem Express

Amustaline (dihydrochloride) [210584-54-6]

10

210584-54-6

Research Use Only

95.0

C22H27Cl4N3O2

507.28

Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) [1] [2] .

O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl.[H]Cl.[H]Cl

2°C to 8°C

12352200