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ANGPTL6 (human) ELISA Kit

Research Use Only
AG-45A-0016YEK
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    ANGPTL6 (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    1.56 to 100ng/ml
  • Assay Sensitivity
    1.2ng/ml
  • Assay Specificity
    Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 1.56 to 100ng/ml. Sensitivity: 1.2ng/ml. Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM) and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance. - Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM) and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Serum levels of angiopoietin-related growth factor are increased in preeclampsia: H. Stepan, et al.; Am. J. Hypertens. 22, 314 (2009)
  • Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis: T. Ebert, et al.; Metabolism 58, 547 (2009)
  • Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome: J. Namkung, et al.; Metabolism 60, 564 (2011)
  • Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease: E.B. Beck, et al.; Eur. J. Prev. Cardiol. 19, 412 (2012)
  • Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)