Anti-17-Hydroxyprogesterone [101.B11.1]

Absolute Antibody

Anti-17-Hydroxyprogesterone [101.B11.1]

9

The antibody binds to 17-OHP with a Kd of 2.9 nM reported for the original antibody.

The antibody binds specifically to 17-OHP, an endogenous progestogen which acts as a chemical intermediate in the synthesis of steroid hormones such as corticosteroids, androgens and estrogens. 17-OHP levels are extremely high in patients who suffer from congenital adrenal hyperplasia (CAH), a disorder of the adrenal glands caused by the deficiency of 21-hydroxylase which catalyses the production of cortisol. This results in the accumulation of the cortisol precursors, and in particular of 17-OHP. Monoclonal antibodies that bind specifically to 17-OHP can therefore be used to measure 17-OHP levels in the diagnosis of CAH.

ELISA

Research Use Only

Monoclonal

101.B11.1

Human

IgG1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203