Anti-17-Hydroxyprogesterone [4B2 (4B2.2.1)]

Absolute Antibody

Anti-17-Hydroxyprogesterone [4B2 (4B2.2.1)]

9

This antibody binds 17alpha-hydroxyprogesterone (17-OHP).

This antibody has good affinity for 17-OHP, a chemical intermediate involved in the biosynthesis of many endogenous steroids like androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids. Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by the deficiency of one of the five enzymes involved in the biosynthesis of corticosteroids. The most common form of the disease is the deficiency of 21-hydroxylase that catalyses the production of cortisol. Due to lack of this enzyme there is an accumulation of high levels of 17alpha-hydroxyprogesterone (17-OHP). This antibody is therefore recommended for detection of high levels of 17-OHP caused by CAH. Fluorescence enzyme immunoassay and micro-enzyme immunoassay for 17-OHP showed that 4B2.2.3 has lowest cross reactivity with other steroids (PMID: 3312820).

ELISA, RadioImmunoAssay

Research Use Only

Monoclonal

4B2 (4B2.2.1)

Mouse

IgG2a

Human

-20°C,2°C to 8°C

12352203