Anti-17-Hydroxyprogesterone [57 (57.G6.1)]

Absolute Antibody

Anti-17-Hydroxyprogesterone [57 (57.G6.1)]

7

This antibody binds 17-OHP, a chemical intermediate involved in the biosynthesis of many endogenous steroids like androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids. Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by the deficiency of one of the five enzymes involved in the biosynthesis of corticosteroids. The most common form of the disease is the deficiency of 21-hydroxylase that catalyses the production of cortisol. Due to lack of this enzyme there is an accumulation of high levels of 17alpha-hydroxyprogesterone (17-OHP). This antibody is therefore recommended for detection of high levels of 17-OHP caused by CAH. Fluorescence enzyme immunoassay and micro-enzyme immunoassay for 17-OHP was used to test the cross reactivity of this antibody with other steroids (PMID: 3312820).

ELISA, RadioImmunoAssay

ELISA; RIA

Research Use Only

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203