Anti-4-1BB [3H3]

Absolute Antibody

Anti-4-1BB [3H3]

7

The binding specificity of this antibody for 4-1BB has been confirmed in ELISA analysis using purified 4-1BB-Ig fusion protein, and immunoprecipitation analysis (Shuford et al, 1997).This antibody is able to block 4-1BBL binding to activated DO.11.10 T cells (Shuford et al, 1997). This antibody reacts with activated T cells, and can costimulate T cell proliferation induced by the 145.2C11 hamster anti- mouse CD3 mAb (Shuford et al, 1997). Equally, when administered to mice, this antibody expands innate immune cells, as well as host T cells (Lin et al, 2010). Administration of this antibody alone induced complete tumor regression in E.G7 tumor-bearing mice (Lin et al, 2010). Binding of this antibody to activated T cells in mice receiving heart allografts led to the rapid rejection of the allograft (Shuford et al, 1997).

ImmunoPrecipitation, ELISA, Other Application

ELISA; IP; stimulatory

Research Use Only

Tumor necrosis factor receptor superfamily member 9

-20°C,2°C to 8°C

12352203