anti-5 Lipoxygenase phospho (Ser523) antibody

Arigo Biolaboratories

anti-5 Lipoxygenase phospho (Ser523) antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

ALOX5

arachidonate 5-lipoxygenase

5-LO; 5-LOX; 5LPG; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; polyunsaturated fatty acid 5-lipoxygenase

Rabbit

IgG

Phosphorylated

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994), fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO is thus likely to provide a valuable tool for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis and atherosclerosis.

Human, Primate

-20°C

12352203