Anti-763.74 [MK2-23]

Absolute Antibody

Anti-763.74 [MK2-23]

9

The antibody binds specifically to the monoclonal antibody 763.74. The 763.74 antibody has neutralising activity against HMW-MAA, a cell surface proteoglycan expressed on more than 90% of melanomas, which has been shown to contribute to the malignant transformation of cancer cells by inducing their invasion, growth and migration. The anti-idiotypic monoclonal antibody MK2-23 mimics HMW-MAA in the binding to 763.67, and can thereby increase the level of antibody production against the antigen in patients with the melanoma. This induces a humoral immune response which has caused the regression of melanomas in some patients and can prolong their survival.

Neutralisation/Blocking

Research Use Only

Monoclonal

MK2-23

Mouse

IgG1

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203