anti-ABRA1 / CCDC98 antibody [ABRA1-01]

Arigo Biolaboratories

anti-ABRA1 / CCDC98 antibody [ABRA1-01]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

ABRA1-01

1 mg/ml

Unconjugated

>95%

ABRAXAS1

abraxas 1, BRCA1 A complex subunit

ABRA1; abraxas protein; BRCA1-A complex subunit Abraxas 1; CCDC98; coiled-coil domain containing 98; FAM175A; family with sequence similarity 175 member A

Mouse

IgG

ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.

-20°C

12352203